DHSMAP (Decay of Haplotype Sharing MAPping software) Changelog Version 1.0 (12/19/00) ======================= - Initial Release Version 1.01 (1/3/01) ======================= - Modified test example; no changes were made to the software. Version 1.02 (1/23/01) ======================= - Fixed bug in estimation of joint allele frequencies for haplotype controls; allow for larger number of alleles at marker loci Version 1.03 (2/8/01) ======================= - Fixed bug in adjustment of controls' haplotype frequencies for when haplotype appears in affecteds but not controls Version 1.04 (3/27/01) ======================= - Fixed bug in computation of derivative of likelihood of mutation process for non-polymorphic locus, i.e., locus at which only one allele appears in affecteds and controls. - Improved grid search for starting values for 1/tau and p (conditional on ancestral haplotype and location of variant) for EM algorithm. Version 2.0 (10/18/01) ======================= - Allowed 2nd order Markov model for background LD; previous versions only allowed Mkv(1) model. - Modified haplotype-frequency estimation routines to allow Bayesian procedure to ensure that all estimates of haplotype frequencies are positive.