1 #program code; set to 1 when fine-mapping 1 #data type for affecteds; #1, if haplotypes available #2, if only genotypes available 6 #number of loci listed in pedfile 2 #number of columns (i.e. fields) to skip in pedfile before #marker genotypes begin 6 #number of markers from pedfile included in analysis 2 1 3 4 5 6 #markers, IN MAP ORDER, where loci in #pedfile are assumed to be given in order #1:n 1 #map type #1, if inter-locus distances in map order (1 fewer than incl. loci) #2, if location on numberline, loci in map order #3, if location on numberline, loci in pedfile order #(for types 2&3, locus farthest left should be assigned #position 0.0) 0.2 0.2 0.2 0.2 0.2 #map, corresponding to map type 1 (all distances #given in cM; see "Tips" for more info.) #for map type=2, map is 0.0 0.2 0.4 0.6 0.8 1.0 #for map type=3, map is 0.2 0.0 0.4 0.6 0.8 1.0 20 #no. of affecteds given in pedfile 20 #no. affected individuals included in analysis 1 2 3 4 5 #Included affected individuals; subjects 6 7 8 9 10 #are labeled in the order in which they are 11 12 13 14 15 #given in pedfile 16 17 18 19 20 1 #controls type #1, if haplotypes available for controls #2, if genotypes available for controls #3, if only allele freqs. avail. for controls, in pedfile order #4, if only allele freqs. avail. for controls, in map order #(see "Tips" for more info. on controls types 3/4) 1 #order of Markov Chain modelling background LD (1 or 2) 1 #Bayesian adjustment to estimated hap. freqs? (1=yes,0=no) 15 #number of controls given in pedfile (only if cont. type is 1/2) 15 #number of controls used in analysis (only if cont. type is 1/2) 21 22 23 24 25 #Included controls (only if cont. type is 1/2) 26 27 28 29 30 31 32 33 34 35 #if controls type is 3 or 4, i.e., only allele frequencies available, #the following is the format for reading in the allele frequencies, #in place of the above (See "Tips" for more info. on this option): # #3 #controls type # #2 1 2 0.5 0.5 # #2 1 2 0.5 0.5 # #2 1 2 0.5 0.5 # #2 1 2 0.5 0.5 # #2 1 2 0.5 0.5 # #2 1 2 0.5 0.5 # #Each line corresponds to a marker. The first entry gives the # #number of alleles for that marker. This is followed by the list # #of alleles and a list of the corresponding frequencies (Note # #that the freqs. must sum to 1.0 for each marker) 1e-5 1e-5 1e-5 1e-5 1e-5 #per meiosis per locus mutation rates 1e-5 #(given in pedfile order) 1 #estimate heterogeneity parameter p? #1, to estimate p #0, to fix p at initial value 0.25 #initial value for p (between 0.0 and 1.0) used for E-M alg. #Names given to results files; each filename must be given on #a new line (for descriptions, see "Output") resout ancout maxout oneout 0 #E_int; interval from the midpoint of which to grow #ancestral hap; 0, if unknown (See "Search Procedures" #for description and "Tips" for advice) 0.1 #max_res (See "Search Procedures" for description and #"Tips" for advice) 20 #map_res (See "Search Procedures" for description and #"Tips" for advice) 20 #max_cand (See "Search Procedures" for description and #"Tips" for advice) 0 # anc_hap_known #0, ancestral haplotypes will be estimated #1, if set of ancestral haplotypes over which to search #is specified #if anc_hap_known=1, it is followed by the number of haplotypes #in the set and then the haplotypes themselves, e.g., # 2 #number of candidate ancestral haplotypes to search over # 1 2 1 1 2 1 # 1 2 2 2 2 2