Case Control tests for Samples with Related Individuals (CC-QLS) Copyright(C) 2003 Catherine Bourgain, Carole Ober, Mary Sara McPeek Homepage: http://galton.uchicago.edu/~mcpeek/software/CCQLSpackage1.3/index.html Release 1.3. March 11,2006 =========================================================== License This program is a free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 2 of the License, or (at your option) any later version. This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY of FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details. You should have received a copy of the GNU General Public License along with this program (see file gpl.txt); if not, write to the Free Software Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA 02111-1307, USA. We request that use of this software be cited in publications as Bourgain, Hoffjan, Nicolae, Newman, Steiner, Walker, Reynolds, Ober and McPeek (2003). Novel Case-Control Test in a Founder Population Identifies P-selectin as an Atopy Susceptibility Locus, American Journal of Human Genetics 73:612-626 To contact the author: Catherine Bourgain INSERM U535 Bat.Leriche Hopital Paul Brousse BP 1000 94817 Villejuif Cedex France Tel : +33 1 45 59 53 85 Fax : +33 1 45 59 53 31 bourgain@vjf.inserm.fr =========================================================== Installation instructions: 1. Download the CC-QLS package which includes the 'CC-QLStest.c' program. 2. Read the files 'Overview', 'Input', 'Output' and 'Tips' carefully to understand the purpose of this program and how it works. 3. Edit the 'Makefile' as necessary according to the instructions in the 'Makefile'. You should only need to make sure that the correct compiler and compiler options for your machine are chosen. 4. Type 'make'. This will build an executable program 'CC-QLStest'. 5. To run the executable program 'CC-QLStest': First, prepare the input files, e.g., 'markid' and 'kinshipcoef' (see the files 'Example' and 'Input' for more details). Then, type ./CC-QLStest markid kinshipcoef 6. Results are output in a file called 'CC-QLStest.out'. Warnings may also be printed in a 'CC-QLStest.err' file. 7. You can test the executable program 'CC-QLStest' by running it with two different sets of input files : - 'markid_Hutt' and 'kinshipcoef_Hutt' corresponding to data from a single large inbred pedigree (2 markers) - 'markid_Sib' and 'kinshipcoef_Sib' corresponding to data from independent outbred nuclear families You can then compare your output in the file 'CC-QLStest.out' with the correct output in the sample output files 'Hutt_CC-QLStest.out' or 'Sib_CC-QLStest.out' 9. The programs stop if any errors are detected in the format of the input files.