****** Results of the ATRIUM Tests ****** There are 1209 individuals from 72 independent families in the phenotype data file. Of these, 174 are affected, 85 are unaffected and 950 are of unknown phenotype. There are 715 individuals listed in the genotype file, 705 of whom are also in the phenotype file. The prevalence value used in the ATRIUM calculations is 0.200000. ***************************************************** Target SNP: rs11252127 (88087 on chr 10) Md = 0.6106 Maximum r^2 = 0.4861 ***************************************************** Tag SNPs rsnumber position rs4881551 149076 rs1105116 230788 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T-C 0.0816 G-T-C 0.4537 A-T-T 0.3479 G-T-T 0.3011 ATRIUM test ATRIUM statistic value = 4.345573 pvalue = 0.0371053 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6714 freq = 0.8386 freq = 0.6689 freq = 0.7114 allele T: freq = 0.3286 freq = 0.1614 freq = 0.3311 freq = 0.2886 ***************************************************** Target SNP: rs10904494 (103934 on chr 10) Md = 0.6659 Maximum r^2 = 0.5284 ***************************************************** Tag SNPs rsnumber position rs4881551 149076 rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-A-T 0.1603 A-T-C 0.1042 A-T-T 0.0598 G-A-C 0.0044 G-A-T 0.0691 G-T-C 0.5875 G-T-T 0.0148 ATRIUM test ATRIUM statistic value = 1.543111 pvalue = 0.214155 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.6691 freq = 0.6917 freq = 0.6659 freq = 0.6677 allele C: freq = 0.3309 freq = 0.3083 freq = 0.3341 freq = 0.3323 ***************************************************** Target SNP: rs7093061 (112109 on chr 10) Md = 0.6999 Maximum r^2 = 0.5570 ***************************************************** Tag SNPs rsnumber position rs4881551 149076 rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-A-T 0.1603 A-T-C 0.1042 A-T-T 0.0598 G-A-C 0.0044 G-A-T 0.0691 G-T-C 0.5875 G-T-T 0.0148 ATRIUM test ATRIUM statistic value = 1.530369 pvalue = 0.216057 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6615 freq = 0.6846 freq = 0.6583 freq = 0.6599 allele T: freq = 0.3385 freq = 0.3154 freq = 0.3417 freq = 0.3401 ***************************************************** Target SNP: rs11253562 (148946 on chr 10) Md = 0.6914 Maximum r^2 = 0.6380 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.061948 pvalue = 0.302771 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6698 freq = 0.6894 freq = 0.6777 freq = 0.6461 allele T: freq = 0.3302 freq = 0.3106 freq = 0.3223 freq = 0.3539 ***************************************************** Target SNP: rs11253563 (148971 on chr 10) Md = 0.6914 Maximum r^2 = 0.6380 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.061948 pvalue = 0.302771 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.3302 freq = 0.3106 freq = 0.3223 freq = 0.3539 allele G: freq = 0.6698 freq = 0.6894 freq = 0.6777 freq = 0.6461 ***************************************************** Target SNP: rs10904596 (149523 on chr 10) Md = 0.6914 Maximum r^2 = 0.6380 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.061948 pvalue = 0.302771 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6698 freq = 0.6894 freq = 0.6777 freq = 0.6461 allele G: freq = 0.3302 freq = 0.3106 freq = 0.3223 freq = 0.3539 ***************************************************** Target SNP: rs9419431 (192356 on chr 10) Md = 0.7416 Maximum r^2 = 0.6382 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10794885 271896 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-A 0.3267 A-C 0.2990 T-A 0.3743 ATRIUM test ATRIUM statistic value = 0.077138 pvalue = 0.781214 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.4317 freq = 0.4354 freq = 0.4478 freq = 0.4203 allele T: freq = 0.5683 freq = 0.5646 freq = 0.5522 freq = 0.5797 ***************************************************** Target SNP: rs10903451 (193471 on chr 10) Md = 0.7416 Maximum r^2 = 0.6382 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10794885 271896 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-A 0.3267 A-C 0.2990 T-A 0.3743 ATRIUM test ATRIUM statistic value = 0.077138 pvalue = 0.781214 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.5683 freq = 0.5646 freq = 0.5522 freq = 0.5797 allele G: freq = 0.4317 freq = 0.4354 freq = 0.4478 freq = 0.4203 ***************************************************** Target SNP: rs11250529 (193800 on chr 10) Md = 0.9975 Maximum r^2 = 0.9293 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.029278 pvalue = 0.310328 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele G: freq = 0.3374 freq = 0.3141 freq = 0.3277 freq = 0.3660 allele T: freq = 0.6626 freq = 0.6859 freq = 0.6723 freq = 0.6340 ***************************************************** Target SNP: rs9419496 (195853 on chr 10) Md = 0.9956 Maximum r^2 = 0.9649 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10736951 271710 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency T-C-C 0.6539 A-C-T 0.0009 T-C-T 0.0687 A-G-C 0.0042 T-G-C 0.0410 A-G-T 0.2300 T-G-T 0.0012 ATRIUM test ATRIUM statistic value = 0.920372 pvalue = 0.337377 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.6991 freq = 0.3220 freq = 0.3292 freq = 0.3620 allele C: freq = 0.3009 freq = 0.6780 freq = 0.6708 freq = 0.6380 ***************************************************** Target SNP: rs7909551 (197829 on chr 10) Md = 0.4156 Maximum r^2 = 0.1988 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs2060138 297807 rs4880568 303504 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T-C 0.1869 A-C-T 0.0587 A-T-T 0.1842 T-T-T 0.9058 ATRIUM test ATRIUM statistic value = 0.828765 pvalue = 0.36263 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.1220 freq = 0.2111 freq = 0.1928 freq = 0.0204 allele T: freq = 0.8780 freq = 0.7889 freq = 0.8072 freq = 0.9796 ***************************************************** Target SNP: rs11250575 (199448 on chr 10) Md = 0.9975 Maximum r^2 = 0.9293 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.029278 pvalue = 0.310328 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6626 freq = 0.6859 freq = 0.6723 freq = 0.6340 allele T: freq = 0.3374 freq = 0.3141 freq = 0.3277 freq = 0.3660 ***************************************************** Target SNP: rs7089302 (204721 on chr 10) Md = 0.9975 Maximum r^2 = 0.9293 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.029278 pvalue = 0.310328 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.6626 freq = 0.6859 freq = 0.6723 freq = 0.6340 allele C: freq = 0.3374 freq = 0.3141 freq = 0.3277 freq = 0.3660 ***************************************************** Target SNP: rs17221197 (214255 on chr 10) Md = 0.9975 Maximum r^2 = 0.9293 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.029278 pvalue = 0.310328 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6626 freq = 0.6859 freq = 0.6723 freq = 0.6340 allele T: freq = 0.3374 freq = 0.3141 freq = 0.3277 freq = 0.3660 ***************************************************** Target SNP: rs2448370 (226452 on chr 10) Md = 0.4156 Maximum r^2 = 0.1988 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs2060138 297807 rs4880568 303504 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T-C 0.1869 A-C-T 0.0587 A-T-T 0.1842 T-T-T 0.9058 ATRIUM test ATRIUM statistic value = 0.828765 pvalue = 0.36263 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.8780 freq = 0.7889 freq = 0.8072 freq = 0.9796 allele T: freq = 0.1220 freq = 0.2111 freq = 0.1928 freq = 0.0204 ***************************************************** Target SNP: rs11250790 (227750 on chr 10) Md = 0.9975 Maximum r^2 = 0.9293 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.029278 pvalue = 0.310328 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.3374 freq = 0.3141 freq = 0.3277 freq = 0.3660 allele G: freq = 0.6626 freq = 0.6859 freq = 0.6723 freq = 0.6340 ***************************************************** Target SNP: rs11250797 (228841 on chr 10) Md = 0.8942 Maximum r^2 = 0.8281 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T 0.2349 T-C 0.7009 T-T 0.0705 ATRIUM test ATRIUM statistic value = 1.050472 pvalue = 0.305398 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.6371 freq = 0.6598 freq = 0.6464 freq = 0.6096 allele C: freq = 0.3629 freq = 0.3402 freq = 0.3536 freq = 0.3904 ***************************************************** Target SNP: rs2496276 (251145 on chr 10) Md = 0.4156 Maximum r^2 = 0.1988 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs2060138 297807 rs4880568 303504 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T-C 0.1869 A-C-T 0.0587 A-T-T 0.1842 T-T-T 0.9058 ATRIUM test ATRIUM statistic value = 0.828765 pvalue = 0.36263 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.8780 freq = 0.7889 freq = 0.8072 freq = 0.9796 allele G: freq = 0.1220 freq = 0.2111 freq = 0.1928 freq = 0.0204 ***************************************************** Target SNP: rs11251059 (258517 on chr 10) Md = 0.5309 Maximum r^2 = 0.4266 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10794885 271896 rs2060138 297807 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-A-C 0.2712 A-A-T 0.0567 T-A-C 0.0315 T-A-T 0.3428 A-C-T 0.2979 ATRIUM test ATRIUM statistic value = 2.082014 pvalue = 0.149043 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.1872 freq = 0.2005 freq = 0.1726 freq = 0.1874 allele G: freq = 0.8128 freq = 0.7995 freq = 0.8274 freq = 0.8126 ***************************************************** Target SNP: rs2448378 (263344 on chr 10) Md = 0.4156 Maximum r^2 = 0.1988 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs2060138 297807 rs4880568 303504 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-T-C 0.1869 A-C-T 0.0587 A-T-T 0.1842 T-T-T 0.9058 ATRIUM test ATRIUM statistic value = 0.828765 pvalue = 0.36263 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.8780 freq = 0.7889 freq = 0.8072 freq = 0.9796 allele C: freq = 0.1220 freq = 0.2111 freq = 0.1928 freq = 0.0204 ***************************************************** Target SNP: rs17221225 (267960 on chr 10) Md = 0.8887 Maximum r^2 = 0.8281 ***************************************************** Tag SNPs rsnumber position rs10736951 271710 rs10508201 281134 rs17221260 315841 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency C-C-T 0.7471 G-C-G 0.0020 G-T-G 0.0905 G-C-T 0.0533 G-T-T 0.1157 ATRIUM test ATRIUM statistic value = 1.700514 pvalue = 0.192221 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.3578 freq = 0.3331 freq = 0.3514 freq = 0.3748 allele G: freq = 0.6422 freq = 0.6669 freq = 0.6486 freq = 0.6252 ***************************************************** Target SNP: rs7912326 (269191 on chr 10) Md = 0.9212 Maximum r^2 = 0.8603 ***************************************************** Tag SNPs rsnumber position rs10736951 271710 rs10508201 281134 rs17221260 315841 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency C-C-T 0.7471 G-C-G 0.0020 G-T-G 0.0905 G-C-T 0.0533 G-T-T 0.1157 ATRIUM test ATRIUM statistic value = 1.713951 pvalue = 0.190474 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.6428 freq = 0.6675 freq = 0.6492 freq = 0.6257 allele T: freq = 0.3572 freq = 0.3325 freq = 0.3508 freq = 0.3743 ***************************************************** Target SNP: rs2496278 (269248 on chr 10) Md = 0.9201 Maximum r^2 = 0.8674 ***************************************************** Tag SNPs rsnumber position rs10736951 271710 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency C-C 0.3025 C-T 0.0367 G-C 0.0319 G-T 0.6288 ATRIUM test ATRIUM statistic value = 2.464823 pvalue = 0.116421 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.2877 freq = 0.3007 freq = 0.2879 freq = 0.2714 allele C: freq = 0.7123 freq = 0.6993 freq = 0.7121 freq = 0.7286 ***************************************************** Target SNP: rs10903739 (278507 on chr 10) Md = 0.9077 Maximum r^2 = 0.8674 ***************************************************** Tag SNPs rsnumber position rs10903752 284165 rs3125023 299526 rs4880568 303504 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency C-C-C 0.0695 C-C-T 0.0993 T-C-T 0.9142 C-T-C 0.2239 ATRIUM test ATRIUM statistic value = 0.686046 pvalue = 0.407513 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.6774 freq = 0.6934 freq = 0.6683 freq = 0.7183 allele G: freq = 0.3226 freq = 0.3066 freq = 0.3317 freq = 0.2817 ***************************************************** Target SNP: rs891735 (295514 on chr 10) Md = 0.9945 Maximum r^2 = 0.8984 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10736951 271710 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-T 0.0009 T-C-C 0.6539 T-C-T 0.0687 A-G-C 0.0042 A-G-T 0.2300 T-G-C 0.0410 T-G-T 0.0012 ATRIUM test ATRIUM statistic value = 0.920372 pvalue = 0.337377 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele G: freq = 0.3009 freq = 0.6780 freq = 0.6708 freq = 0.6380 allele T: freq = 0.6991 freq = 0.3220 freq = 0.3292 freq = 0.3620 ***************************************************** Target SNP: rs2163579 (296913 on chr 10) Md = 0.9635 Maximum r^2 = 0.9000 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency T-C 0.7009 A-T 0.2349 T-T 0.0705 ATRIUM test ATRIUM statistic value = 0.471679 pvalue = 0.492216 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6109 freq = 0.6270 freq = 0.6225 freq = 0.5865 allele G: freq = 0.3891 freq = 0.3730 freq = 0.3775 freq = 0.4135 ***************************************************** Target SNP: rs10903803 (303000 on chr 10) Md = 0.9609 Maximum r^2 = 0.8622 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 rs17221260 315841 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-G 0.0020 A-T-G 0.1310 A-C-T 0.0039 A-T-T 0.1187 T-C-T 0.7493 ATRIUM test ATRIUM statistic value = 2.039827 pvalue = 0.153227 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.3180 freq = 0.2905 freq = 0.3218 freq = 0.3372 allele G: freq = 0.6820 freq = 0.7095 freq = 0.6782 freq = 0.6628 ***************************************************** Target SNP: rs4880567 (303304 on chr 10) Md = 0.5247 Maximum r^2 = 0.4013 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 rs2060138 297807 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-T 0.0114 A-T-T 0.4704 T-C-T 0.7386 T-T-C 0.0006 T-T-T 0.0070 ATRIUM test ATRIUM statistic value = 2.084489 pvalue = 0.148802 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.3616 freq = 0.3821 freq = 0.3386 freq = 0.3517 allele T: freq = 0.6384 freq = 0.6179 freq = 0.6614 freq = 0.6483 ***************************************************** Target SNP: rs10903806 (304421 on chr 10) Md = 0.9667 Maximum r^2 = 0.8600 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 rs17221260 315841 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-G 0.0020 A-T-G 0.1310 A-C-T 0.0039 A-T-T 0.1187 T-C-T 0.7493 ATRIUM test ATRIUM statistic value = 2.020747 pvalue = 0.155163 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.3326 freq = 0.3056 freq = 0.3360 freq = 0.3518 allele G: freq = 0.6674 freq = 0.6944 freq = 0.6640 freq = 0.6482 ***************************************************** Target SNP: rs11251372 (305644 on chr 10) Md = 0.9667 Maximum r^2 = 0.8600 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 rs17221260 315841 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-G 0.0020 A-T-G 0.1310 A-C-T 0.0039 A-T-T 0.1187 T-C-T 0.7493 ATRIUM test ATRIUM statistic value = 2.020747 pvalue = 0.155163 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele G: freq = 0.6674 freq = 0.6944 freq = 0.6640 freq = 0.6482 allele T: freq = 0.3326 freq = 0.3056 freq = 0.3360 freq = 0.3518 ***************************************************** Target SNP: rs2018975 (307501 on chr 10) Md = 0.9978 Maximum r^2 = 0.9319 ***************************************************** Tag SNPs rsnumber position rs10794885 271896 rs3125023 299526 rs4880568 303504 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-C 0.0454 A-T-C 0.0224 A-C-T 0.6323 C-C-C 0.0102 C-T-C 0.2772 C-C-T 0.0124 ATRIUM test ATRIUM statistic value = 0.728827 pvalue = 0.393264 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6862 freq = 0.6968 freq = 0.6768 freq = 0.6954 allele T: freq = 0.3138 freq = 0.3032 freq = 0.3232 freq = 0.3046 ***************************************************** Target SNP: rs7896421 (309879 on chr 10) Md = 0.9667 Maximum r^2 = 0.8600 ***************************************************** Tag SNPs rsnumber position rs1476130 264675 rs10508201 281134 rs17221260 315841 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency A-C-G 0.0020 A-T-G 0.1310 A-C-T 0.0039 A-T-T 0.1187 T-C-T 0.7493 ATRIUM test ATRIUM statistic value = 2.020747 pvalue = 0.155163 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele C: freq = 0.6674 freq = 0.6944 freq = 0.6640 freq = 0.6482 allele T: freq = 0.3326 freq = 0.3056 freq = 0.3360 freq = 0.3518 ***************************************************** Target SNP: rs10903832 (310954 on chr 10) Md = 0.5583 Maximum r^2 = 0.4758 ***************************************************** Tag SNPs rsnumber position rs1105116 230788 rs2060138 297807 There are 705 individuals with at least one tag SNP genotyped. Of these, 174 are affected, 85 are unaffected and 446 are of unknown phenotype. Tag SNP haplotype frequency estimates in full sample Haplotype Frequency G-T 0.0430 T-T 1.2597 ATRIUM test ATRIUM statistic value = 2.376510 pvalue = 0.123172 Allele frequency estimates for the untyped SNP full sample affected unaffected unknown allele A: freq = 0.8708 freq = 0.8631 freq = 0.8930 freq = 0.8724 allele G: freq = 0.1292 freq = 0.1369 freq = 0.1070 freq = 0.1276