Mary Sara McPeek

For publications, please click this link: Publications

Address

University of Chicago
Department of Statistics
5734 S. University Ave.
Chicago, IL 60637
email: mcpeek@galton.uchicago.edu
office phone: (773) 702-7554
fax: (773) 702-9810

Current Position

2006 - present Professor, Department of Statistics, Department of Human Genetics, and the College; Member, Committee on Genetics, Genomics and Systems Biology; Senior Fellow, Computation Institute, University of Chicago

Past Positions

1981-1987 (summers) Head Math Instructor, Instructor, Teaching Assistant, The Johns Hopkins University Center for Talented Youth Summer Residential Programs

1988-1993 (various semesters) Teaching Assistant and Research Assistant, Department of Statistics, University of California at Berkeley

1993-2000 Assistant Professor, Department of Statistics and the College, University of Chicago

1994-1995 Visitor, Math/Biology Lab, Department of Mathematics, University of Southern California

1994-present Member of Committee on Genetics, Genomics and Systems Biology, University of Chicago

2000-2006 Associate Professor, Department of Statistics, Department of Human Genetics, Committee on Genetics, Genomics and Systems Biology, and the College, University of Chicago

2000 Visiting Fellow, Functional Genomics Program at IPAM, UCLA

2002 The Edward Rotan Visiting Professorship, University of Texas M.D. Anderson Cancer Center

2003-present Senior Fellow in Computation Institute, University of Chicago

Associate Editorships

Biometrics, 2000-2002, 2003-2006
Genetics, 2005-2008
Statistica Sinica, 2005-2008
Statistical Applications in Genetics and Molecular Biology, 2002 - present

Education

A.B. Mathematics and A.M. Statistics, Harvard University, 1988
Ph.D Statistics, University of California at Berkeley, 1993

Awards, Fellowships

1984 NCR Centennial Scholar (2 per state)
1984 National Merit Scholar
1984 U.S.A. Presidential Scholar (~2-3 per state)
1987 The Radcliffe Junior Science Prize, Harvard University
1987 Phi Beta Kappa
1988 The Berkeley Fellowship (~0-1 per department)
1988 National Science Foundation Graduate Fellowship
1993 The Evelyn Fix Memorial Medal and Citation, Statistics Department, University of California, Berkeley
1997 NIH FIRST Award
2000 Visiting Fellow, Functional Genomics Program at IPAM, UCLA
2002 The Edward Rotan Visiting Professorship, University of Texas M.D. Anderson Cancer Center
2008 IMS Medallion Lecturer (2008 ENAR Annual Meeting)

Current Grants

Principal Investigator: NIH/NIHGR 1 R01 HG001645 (McPeek) "Methods for Human Genetic Mapping" 09/01/97 - 07/31/13

Co-Inv: NIH/NIGMS R01 GM058686-07 (Wu) "MicroRNA Evolution and Species Divergence in Drosophila" 07/01/08 - 06/30/11

Past Grants

Co-Inv: NIH/NCHGR 5 R01 HG0109302 (Speed) ``Gene Mapping" 07/01/94 - 06/30/97

Collaborator: NIH/NICHD 5 R01 HD21244-12 (Ober) ``Immunogenetic Studies of Fertility" 12/1/94 - 11/30/97

Co-PI: Packard Foundation Interdisciplinary Science Program (Mets) ``The University of Chicago Biomics Project" 09/01/01 - 08/31/04

Collaborator: NIH/NHLBI 1 R01 HL66533 (Ober) "Characterizing a 5p-linked BHR susceptibility locus" 9/30/00 - 8/31/05

Co-Inv: NIH/NIDDK 1 R01 DK55889 (Cox) "Robust Methods for Identifying Genes for Complex Traits" 9/01/98 - 08/31/06

Co-Inv: NIH/NHLBI U01 HL084715 (Cox) "Genome-wide Association Mapping of Metabolic, Lung and Cardiovascular Phenotypes" 06/15/06 - 05/31/09

Other Professional Activities

Member: Institute of Mathematical Statistics, International Biometrics Society (ENAR), American Statistical Association, American Society of Human Genetics, International Genetic Epidemiology Society

Referee: American Journal of Human Genetics, Annals of Human Genetics, Annals of Statistics, Biometrics, Communications in Statistics, Genetic Analysis Workshop, Genetic Epidemiology, Genetics, Human Heredity, IMA Volumes in Mathematics and Its Applications, Journal of Applied Probability, Journal of the American Statistical Association, Journal of Computational Biology, Journal of the Royal Statistical Society Series B, Kluwer Academic Publishers, Nature Genetics, NIH, NSF, Pacific Symposium on Biocomputing, PLoS Genetics, Statistical Science, Theoretical Population Biology, Wellcome Trust

Organizer of an IMS invited paper session on Statistics and Genetics for the 1995 Joint Meetings of the IMS and SSC, Montreal, July 1995

Organizer of an IMS/WNAR invited paper session on Statistics and Genetics for the 1995 Joint Meetings of the WNAR and IMS, Stanford, June 1995

Member, 1995 IMS Committee on New Researchers

Organizer of an IMS invited paper session on Statistics and Genetics for the 1998 Joint Meetings of the ASA, ENAR, WNAR, IMS, SSC, Dallas, August 1998

Organizer of an IMS invited paper session on Statistics and Genetics for the 1999 Joint Meetings of the ASA, ENAR, WNAR, IMS, SSC, Baltimore, August 1999

IMS Contributed Paper Chair for 1999 Joint Statistical Meetings, Baltimore, August 1999

Ad hoc member of Genome Study Section, National Institutes of Health, November 2000, June 2001

Member of organizing committee, MSRI Workshop on Genetics of Complex Disease, February 2004

Ad hoc member of Mammalian Genetics Study Section, National Institutes of Health, June 2004

Ad hoc member of Genomics Computational Biology and Technology Study Section, National Institutes of Health, March 2006

Member of scientific committee, Second Midwest Statistics Research Colloquium, March 2009

Students

B.A.

Peter Hammack, 1994, thesis: "Empirical testing of various models of the term structure of interest rates"

Qian Zhang, 2009, thesis: "Case-control association testing on X chromosome in related individuals"

M.S.

Chris Cleveland, 1997, thesis: "An analysis of mammary tumor development in rats"

Richard Wherry, 1999, thesis: "Estimating Interference in Chlamydomonas reinhardtii from Tetrad Data Summarized as Marginal Counts"

Ted Lin, 1999, thesis: "Statistical analysis of segregation distortion in hereditary retinoblastoma using sperm typing data"

Soohyun Park, 2001, thesis: "Analysis of segregation distortion in the HLA complex using sperm typing data"

Xiaodong Wu, 2004, thesis: "A trend test for association in case-control studies with pedigree data"

Han Gao, 2004 (secondary advisor; primary advisor: Mark Abney), thesis: "Estimation of variance components of lymphocytes and cortisol in an inbred population"

Xiaochen Cai, current

Sheng Zhong, current

Ph.D.

Andrew Strahs (2001) "Multipoint fine-scale linkage disequilibrium mapping by the decay of haplotype sharing"
Biostatistician, Wyeth Research

Lei Sun (2001) "Two statistical problems in human genetics: I. Detection of pedigree errors; II. Identification of polymorphisms that explain a linkage result"
Associate Professor, University of Toronto

Jian Zhang (2001) "Linkage disequilibrium mapping by the decay of haplotype sharing in a founder population"
UBS AG Investment Bank

Liping Tong (2004) "Statistical inference for multi-color optical mapping"
Assistant Professor, Loyola University

Maoxia Zheng (2005) "Two statistical problems in gene mapping"
Biostatistician, Genentech

Timothy Thornton (2005) "Statistical inference for genetic analysis in related individuals"
Assistant Professor, University of Washington

Zuoheng Wang, (2009) "Statistical methods for haplotype association analysis of complex traits"
Assistant Professor, Yale University

Yan Li, current

Post-Docs

Xiaodong Wu (jointly mentored with Prof. Carole Ober of Department of Human Genetics, 1998-2000) "Best linear unbiased allele-frequency estimation in complex pedigrees"
Biostatistician, Johnson and Johnson

Mark Abney (jointly mentored with Prof. Carole Ober of Department of Human Genetics, 1999-2001) "Estimation of variance components of quantitative traits in a founder population" and ``Broad and narrow heritabilities of quantitative traits in a founder population" and "Quantitative trait homozygosity and association mapping and empirical genome-wide significance in large complex pedigrees: fasting serum insulin level in the Hutterites"
Research Associate (Associate Professor), University of Chicago

Catherine Bourgain (jointly mentored with Prof. Carole Ober of Department of Human Genetics, 2002) "Novel case-control test in a founder population identifies P-selectin as an atopy susceptibility locus" and "Testing for Hardy-Weinberg in populations with known genealogy"
Scientist, INSERM, France

Jian Zhang (2003-2004) "Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals" and ``Using linkage to inform positional cloning"
see above

Maoxia Zheng (2006) "Multipoint linkage disequilibrium mapping with haplotype block structure" and "Identification of pairs of variants that explain a linkage result"
see above

Jun Zhang (2007) "Laplacian eigenfunctions learn population structure"
researcher, University of Chicago

Johanna Jakobsdottir, current

Xiaowei Wu, current